Microenvironmental Traits of Classical Hodgkin’s Lymphoma in Adolescents and Their Prognostic Impact
We showed that microenvironment of cHL in adolescent patients is enriched with potential therapeutic targets of ICPI that may be considered for therapeutic applications. Furthermore, the presence of PD-1 expressing T-cells strongly relates to advanced stage disease and a low density of CD8+ T lymphocytes is associated with recurrence and progression of disease.
Authors
- Maurizio Baldassarre (ORCID: https://orcid.org/0000-0001-7865-394X)
- Giovanna Motta (ORCID: https://orcid.org/0000-0001-5593-5397)
- Giulia Gabrielli (ORCID: https://orcid.org/0000-0002-1162-8712)
- Elena Sabattini (ORCID: https://orcid.org/0000-0002-4136-3591)
- Maura Rossi (ORCID: https://orcid.org/0000-0002-9522-1601)
- Arcangelo Prete (ORCID: https://orcid.org/0000-0002-6823-3797)
- Matteo Carella (ORCID: https://orcid.org/0000-0001-5997-6452)
- Simona Righi (ORCID: https://orcid.org/0000-0003-3114-3998)
- Elena Facchini (ORCID: https://orcid.org/0000-0002-3335-1259)
- Clara Bertuzzi (ORCID: https://orcid.org/0000-0001-9526-9261)
- Pier Luigi Zinzani (ORCID: https://orcid.org/0000-0002-2112-2651)
- Claudio Agostinelli (ORCID: https://orcid.org/0000-0002-4945-1422)
Institutions
- Istituto di Ematologia di Bologna (IT)
- Azienda USL di Bologna (IT)
- University of Naples Federico II (IT)
- University of Bologna (IT)
Publication Details
- Journal
- Cancers
- Published
- 2024-12-18
- DOI
- https://doi.org/10.3390/cancers16244210
- Citations
- 1
- Primary Topic
- Lymphoma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.42
Funders
- Ministero della Salute