Exploring Bone Morphogenetic Protein-2 and -4 mRNA Expression and Their Receptor Assessment in a Dynamic In Vitro Model of Vascular Calcification
The increase in <i>BMP-2/4</i> in co-culture suggests that these genes might promote the switch towards an osteogenic-like phenotype, data also supported by the rise of both <i>BMPR-1a</i> and <i>BMPR-2</i>. Thus, our findings provide insights into the mechanisms by which dynamic co-culture modulates the <i>BMP</i> system activation in an environment mimicking <i>in vivo</i> VC's cellular and mechanical characteristics.
Authors
- Antonella Cecchettini (ORCID: https://orcid.org/0000-0002-2659-026X)
- Elisa Persiani (ORCID: https://orcid.org/0000-0001-6943-8199)
- Silvia Del Ry (ORCID: https://orcid.org/0000-0001-7163-245X)
- Letizia Guiducci (ORCID: https://orcid.org/0000-0003-3330-3238)
- Manuela Cabiati (ORCID: https://orcid.org/0000-0002-0811-6257)
- Elisa Ceccherini (ORCID: https://orcid.org/0000-0003-3912-2753)
- Agnese Sgalippa (ORCID: https://orcid.org/0000-0002-6395-3525)
- Federico Vozzi (ORCID: https://orcid.org/0000-0001-5457-2328)
- Ilaria Gisone (ORCID: https://orcid.org/0000-0002-6579-7650)
Institutions
- University of Pisa (IT)
- Scuola Superiore Sant'Anna (IT)
- Istituto di Fisiologia Clinica (IT)
Publication Details
- Journal
- Cells
- Published
- 2024-12-18
- DOI
- https://doi.org/10.3390/cells13242091
- Citations
- 4
- Primary Topic
- Orthopaedic implants and arthroplasty
- Type
- article
- Field-Weighted Citation Impact
- 2.29