Follistatin From hiPSC-Cardiomyocytes Promotes Myocyte Proliferation in Pigs With Postinfarction LV Remodeling
<sup>KO/OE</sup>hiPSC-CM spheroids significantly improved cardiac function and reduced infarct size in pig hearts after ischemia/reperfusion injury by secreting follistatin, which upregulated HIPPO/YAP signaling and proliferation in endogenous pig cardiomyocytes.
Authors
- Gregory P. Walcott (ORCID: https://orcid.org/0000-0002-9807-7422)
- Jack M. Rogers (ORCID: https://orcid.org/0000-0002-3236-4154)
- Yuhua Wei (ORCID: https://orcid.org/0000-0003-0140-873X)
- Jianyi Zhang (ORCID: https://orcid.org/0000-0002-3955-6554)
- Daniel J. Garry (ORCID: https://orcid.org/0000-0002-8970-7365)
- Bijay Guragain (ORCID: https://orcid.org/0000-0002-6859-148X)
- Thanh Nguyen (ORCID: https://orcid.org/0000-0002-8440-1594)
- Manuel Rosa‐Garrido (ORCID: https://orcid.org/0000-0002-2169-3972)
- Lei Ye (ORCID: https://orcid.org/0000-0001-5039-6224)
- Hanyu Zhang (ORCID: https://orcid.org/0000-0003-1810-7677)
- Akazha Green (ORCID: https://orcid.org/0009-0003-1768-6379)
- Xiaoxiao Geng
Institutions
- University of Minnesota (US)
- University of Alabama at Birmingham (US)
Publication Details
- Journal
- Circulation Research
- Published
- 2024-12-18
- DOI
- https://doi.org/10.1161/circresaha.124.325562
- Citations
- 5
- Primary Topic
- Pluripotent Stem Cells Research
- Type
- article
- Field-Weighted Citation Impact
- 1.17