Comparing the protection of heterologous booster of inhaled Ad5-nCoV vaccine and hybrid immunity against Omicron BA.5 infection: a cohort study of hospital staff in China
We found that hybrid immunity could provide a high level of protection against Omicron infection, while a heterologous inhaled Ad5-nCoV booster conferred a moderate level of protection. Our findings supported the rollout of a heterologous vaccination strategy regardless of preexisting vaccine coverage.
Authors
- Chunyan Yan (ORCID: https://orcid.org/0000-0002-9209-6630)
- Zihao Guo (ORCID: https://orcid.org/0000-0001-9002-0483)
- Zhaohui Luo
- Ka Chun Chong (ORCID: https://orcid.org/0000-0001-5610-1298)
- Naijun Tang (ORCID: https://orcid.org/0000-0002-1177-252X)
- Kailu Wang (ORCID: https://orcid.org/0000-0002-3462-4677)
- Yongkang Ni
- Hui Li (ORCID: https://orcid.org/0000-0002-4611-7808)
- Shi Zhao (ORCID: https://orcid.org/0000-0001-8722-6149)
- Liang Yin (ORCID: https://orcid.org/0009-0008-5338-2993)
- Kai Wang (ORCID: https://orcid.org/0000-0002-8460-9926)
- Ting Zeng (ORCID: https://orcid.org/0000-0001-6041-4211)
- Jianghong Dai (ORCID: https://orcid.org/0000-0003-1283-3969)
- Shengzhi Sun (ORCID: https://orcid.org/0000-0001-9635-7853)
- Jing Liang
- Lan Wang (ORCID: https://orcid.org/0009-0005-3726-5701)
Institutions
- Xinjiang Medical University (CN)
- Chinese University of Hong Kong (HK)
- Capital Medical University (CN)
- City University of Hong Kong, Shenzhen Research Institute (CN)
- Sixth Affiliated Hospital of Xinjiang Medical University (CN)
- Tianjin Medical University (CN)
- University of Hong Kong (HK)
Publication Details
- Journal
- BMC Infectious Diseases
- Published
- 2024-12-18
- DOI
- https://doi.org/10.1186/s12879-024-10250-1
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Xinjiang Medical University
- Tianjin Medical University
- National Science and Technology Major Project