Computational deconvolution of cell type-specific gene expression in COPD and IPF lungs reveals disease severity associations
Utilization of RNA-seq deconvolution enabled us to pinpoint cell types present in the lungs that are associated with the severity of COPD and IPF. This knowledge offers valuable insight into the alterations within tissues in more advanced illness, ultimately providing a better understanding of the underlying pathological processes that drive disease progression.
Authors
- Lucas Barwick
- Jarrett D. Morrow (ORCID: https://orcid.org/0000-0002-5670-5865)
- Gerard J. Criner (ORCID: https://orcid.org/0000-0003-1267-3483)
- Kevin R. Flaherty (ORCID: https://orcid.org/0000-0001-7686-0291)
- Michele Gentili (ORCID: https://orcid.org/0000-0003-2282-2227)
- Auyon Ghosh (ORCID: https://orcid.org/0000-0003-0334-4039)
- Jeong H. Yun (ORCID: https://orcid.org/0000-0002-4361-8295)
- Robert A. Wise (ORCID: https://orcid.org/0000-0002-8353-2349)
- Edwin K. Silverman (ORCID: https://orcid.org/0000-0002-3641-3822)
- Kangjin Kim (ORCID: https://orcid.org/0000-0002-3966-3309)
- Kevin K. Brown (ORCID: https://orcid.org/0000-0002-9209-3261)
- Frank C. Sciurba (ORCID: https://orcid.org/0000-0001-7468-2225)
- Dawn L. DeMeo (ORCID: https://orcid.org/0000-0001-9653-0636)
- ANDREW HAR LIMPER (ORCID: https://orcid.org/0000-0001-5671-6874)
- Min Hyung Ryu (ORCID: https://orcid.org/0000-0003-3071-7363)
- Peter J. Castaldi (ORCID: https://orcid.org/0000-0001-9920-4713)
- Craig P. Hersh (ORCID: https://orcid.org/0000-0002-1342-4334)
- Fernando J. Martinez (ORCID: https://orcid.org/0000-0002-2412-3182)
- Michael H. Cho
Institutions
- Brigham and Women's Hospital (US)
- Harvard University (US)
- Johns Hopkins University (US)
- University of Pittsburgh (US)
- SUNY Upstate Medical University (US)
- Cornell University (US)
- Johns Hopkins Medicine (US)
- National Jewish Health (US)
- Presbyterian Hospital (US)
- Michigan Medicine (US)
- Emmes (United States) (US)
- Mayo Clinic in Arizona (US)
- Temple University (US)
- University of Colorado Denver (US)
Publication Details
- Journal
- BMC Genomics
- Published
- 2024-12-18
- DOI
- https://doi.org/10.1186/s12864-024-11031-5
- Citations
- 3
- Primary Topic
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Type
- article
- Field-Weighted Citation Impact
- 1.26
Funders
- Alpha-1 Foundation
- Canadian Institutes of Health Research
- National Heart, Lung, and Blood Institute