Addressing lung truncation in 99mTc-MAA SPECT/CT for 90Y microsphere radioembolization treatment planning
LSF and LMD can be estimated for <sup>90</sup>Y radioembolization using truncated lung coverage data in MAA-SPECT/CT. Empirical models to predict lung counts at full lung coverage produced LSF and LMD estimates with minimal bias and uncertainty. With lung/liver boundary adjustments, all SPECT/CT methods assessed in this work yielded LMD estimates comparable to ground truth, even down to 50% lung coverage.
Authors
- Christopher Malone (ORCID: https://orcid.org/0000-0003-2458-973X)
- Justin Mikell (ORCID: https://orcid.org/0000-0003-0679-7199)
- Richard A. Laforest (ORCID: https://orcid.org/0000-0002-0238-1439)
- Tyler J. Fraum (ORCID: https://orcid.org/0000-0001-6573-5081)
- John Karageorgiou (ORCID: https://orcid.org/0000-0002-4966-1139)
- Dario Giardinà
- M.A. Thomas (ORCID: https://orcid.org/0000-0002-3533-740X)
Institutions
- Washington University in St. Louis (US)
- Mallinckrodt (United States) (US)
Publication Details
- Journal
- EJNMMI Physics
- Published
- 2024-12-18
- DOI
- https://doi.org/10.1186/s40658-024-00705-4
- Citations
- 4
- Primary Topic
- Lung Cancer Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.68