Single-Cell RNA Sequencing Reveals That C5AR1 in Follicle Monocyte Cells Could Predict the Development of POI

Our findings revealed that the interaction between monocytes and granulocytes may contribute to the development of POI. We found that POI lacked HLA-DRB5 expression and had impaired antigen processing and presentation activities. To a certain extent, C5AR1 could be used to predict the development of POI.

Authors

Lina Yuan
Ying Han
Junrong Diao
Haining Luo (ORCID: https://orcid.org/0000-0003-2409-3355)
Shuai Zhang
Xinyan Wang (ORCID: https://orcid.org/0000-0002-3690-2335)
Yaqiong Ping
Yunshan Zhang (ORCID: https://orcid.org/0009-0004-8403-2997)

Institutions

Tianjin Central Hospital of Gynecology Obstetrics (CN)

Publication Details

Journal: Journal of Inflammation Research
Published: 2024-12-01
DOI: https://doi.org/10.2147/jir.s490996
Citations: 2
Primary Topic: Reproductive System and Pregnancy
Type: article
Field-Weighted Citation Impact: 0.48

Funders

Tianjin Science and Technology Program

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article

Single-Cell RNA Sequencing Reveals That C5AR1 in Follicle Monocyte Cells Could Predict the Development of POI

Lina Yuan, Ying Han, Junrong Diao, Haining Luo et al.

Dec 1, 2024

2 citations

Journal of Inflammation Research

Reproductive System and Pregnancy

0.48

article

Single-Cell RNA Sequencing Reveals That C5AR1 in Follicle Monocyte Cells Could Predict the Development of POI

Lina Yuan, Ying Han, Junrong Diao, Haining Luo, Shuai Zhang, Xinyan Wang, Yaqiong Ping, Yunshan Zhang

December 1, 2024article en

2 citations

Abstract

Our findings revealed that the interaction between monocytes and granulocytes may contribute to the development of POI. We found that POI lacked HLA-DRB5 expression and had impaired antigen processing and presentation activities. To a certain extent, C5AR1 could be used to predict the development of POI.

Journal of Inflammation ResearchVol. Volume 17

Tianjin Central Hospital of Gynecology Obstetrics (CN)

Tianjin Science and Technology Program

Zero hunger

Openalex Percentile: Top 33%

Reproductive System and Pregnancy

0.48

DOI Open Access PDF OpenAlex

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