Cover Feature: A CH<sub>4</sub>‐Driven Ion Cloud‐Stretched Approach Enables ICP‐<i>q</i>MS for Multiplex Single‐Cell Analysis (Chem. Eur. J. 71/2024)
Cells are heterogenous like different human individuals. Labeling cells by using lanthanide (Ln)-tagged macrophage MS2 capsid-conjugated antibody toward the corresponding cell-surface biomarkers, and stretching the ICP-generated ion cloud duration of the Ln-labeled single-cell by using CH4 in collision-reaction cell (CRC), allowed the acquisition of multi-m/z signals by ICP-quadrupole (q)-MS (ICP-(CH4-CRC)-qMS). Multiplex analysis of the Ln-labeled single cells by using ICP-(CH4-CRC)-qMS recovers their intrinsically colorful features. More information can be found in the Research Article by X. Yan, Q. Wang and co-workers (DOI: 10.1002/chem.202402289).
Authors
- Qiuquan Wang (ORCID: https://orcid.org/0000-0002-5166-4048)
- Zhengxian Lv
- Limin Yang (ORCID: https://orcid.org/0000-0001-9324-6234)
- Xiaowen Yan (ORCID: https://orcid.org/0000-0001-6608-6044)
- Zhen Liu (ORCID: https://orcid.org/0000-0002-8440-2554)
- Chen Shi (ORCID: https://orcid.org/0000-0002-9500-0681)
Institutions
- Xiamen University (CN)
- Tan Kah Kee Innovation Laboratory (CN)
Publication Details
- Journal
- Chemistry - A European Journal
- Published
- 2024-12-18
- DOI
- https://doi.org/10.1002/chem.202487104
- Primary Topic
- Ion-surface interactions and analysis
- Type
- article
- Field-Weighted Citation Impact
- 0.00