Palladium-Catalyzed Domino Carboetherification Reactions: Synthesis of Bis-Heterocycles Bearing Isoxazoline and Methyleneindole Motifs
A novel and highly efficient Pd-catalyzed approach for the synthesis of bis-heterocycles featuring both isoxazoline and methyleneindole motifs is demonstrated. The in situ formation of vinyl Pd(II) species through an alkyne-tethered carbamoyl chloride cyclization is crucial, and the innovative Pd-catalyzed carboetherification of β,γ-unsaturated oximes with vinyl Pd(II) species has been developed. This method is not only operationally straightforward but also exhibits a broad substrate scope and excellent functional group tolerance.
Authors
- Shuaijie Wu
- Youzhou He (ORCID: https://orcid.org/0000-0002-7586-2321)
- Chao‐Guo Yan (ORCID: https://orcid.org/0000-0002-2777-9582)
- Huijun Dong (ORCID: https://orcid.org/0000-0002-6899-879X)
- Wenbo Li (ORCID: https://orcid.org/0000-0002-5383-5488)
- Lei Wang (ORCID: https://orcid.org/0000-0002-8792-0234)
- Qing Wu (ORCID: https://orcid.org/0009-0003-4618-1580)
- Jing Sun (ORCID: https://orcid.org/0000-0002-8341-7367)
- Feifei Jin
Institutions
- East China Normal University (CN)
- Yangzhou University (CN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2024-12-18
- DOI
- https://doi.org/10.1021/acs.joc.4c02679
- Citations
- 5
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 1.25
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Jiangsu Province