Tadalafil Enhances the Therapeutic Efficacy of Mesenchymal Stem Cells-Derived Exosomes in Pulmonary Hypertension by Upregulating miR-29a-3p
MSC treated with tadalafil can secrete better exosomes. MSC<sup>TAD-Exo</sup> may enhance anti-inflammatory and anti-vascular remodeling properties by upregulating mir-29a-3p expression, providing a novel idea for PH therapy. Future studies could explore the clinical application of this finding.
Authors
- Lei Tian (ORCID: https://orcid.org/0000-0001-8968-5277)
- Yi Liu (ORCID: https://orcid.org/0000-0002-2338-7055)
- Lina Shan (ORCID: https://orcid.org/0000-0003-1187-9156)
- Xue Jiao (ORCID: https://orcid.org/0000-0002-4172-6794)
- Xianbao Shi
- Qian Zhong (ORCID: https://orcid.org/0000-0001-8354-5839)
- Xin Li (ORCID: https://orcid.org/0000-0003-0469-5121)
- Hongyan Li (ORCID: https://orcid.org/0000-0001-7260-2957)
- Changqing He
- Churong Zhao
- Lixuan Guo
- Gaoge Fu
Institutions
- Yichun University (CN)
- Panzhihua Central Hospital (CN)
- First People's Hospital of Jingzhou (CN)
- Jinzhou Medical University (CN)
Publication Details
- Journal
- International Journal of Nanomedicine
- Published
- 2024-12-01
- DOI
- https://doi.org/10.2147/ijn.s493047
- Citations
- 6
- Primary Topic
- Pulmonary Hypertension Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.51