White matter free water mediates the associations between placental growth factor, white matter hyperintensities, and cognitive status
NCT06284213 HIGHLIGHTS: PlGF is a promising blood-based biomarker for vascular cognitive impairment. In MarkVCID, higher PlGF was associated with accumulated white matter FW on MRI. FW mediated the association between higher PlGF and MRI-visible white matter injury. FW mediated the association between PlGF and worse CDR scale. PlGF may contribute to cognitive dysfunction via accumulated interstitial fluid.
Authors
- Donna M. Wilcock (ORCID: https://orcid.org/0000-0003-3388-1564)
- Sudha S. Seshadri (ORCID: https://orcid.org/0000-0001-6135-2622)
- Abhay P. Sagare (ORCID: https://orcid.org/0000-0002-8178-3785)
- Joel H. Kramer (ORCID: https://orcid.org/0000-0002-2917-8297)
- Russell P. Tracy (ORCID: https://orcid.org/0000-0002-0080-2420)
- Pauline Maillard (ORCID: https://orcid.org/0000-0003-3516-6345)
- Gary A. Rosenberg (ORCID: https://orcid.org/0000-0001-7426-7064)
- Kristin Schwab (ORCID: https://orcid.org/0000-0001-5723-9109)
- Steven Mark Greenberg (ORCID: https://orcid.org/0000-0003-1792-8887)
- Danny J.J. Wang (ORCID: https://orcid.org/0000-0002-0840-7062)
- Abhay Moghekar (ORCID: https://orcid.org/0000-0001-9464-1551)
- Charles DeCarli (ORCID: https://orcid.org/0000-0003-1914-2693)
- Jason D. Hinman (ORCID: https://orcid.org/0000-0002-0872-5044)
- Manik Vohra (ORCID: https://orcid.org/0000-0002-5804-6189)
- Keith Vossel
- Herpreet Singh (ORCID: https://orcid.org/0000-0003-3797-7301)
- Pia Kivisäkk (ORCID: https://orcid.org/0000-0001-9708-7509)
- Fanny M. Elahi (ORCID: https://orcid.org/0000-0003-4663-4992)
- Kyle C. Kern (ORCID: https://orcid.org/0000-0002-2703-7669)
- Karl G. Helmer (ORCID: https://orcid.org/0000-0002-5113-6843)
- Marissa L. Thirion
- Tiffany Lee (ORCID: https://orcid.org/0000-0002-0032-0608)
- Jeffrey F. Thompson
- Claudia L. Satizábal (ORCID: https://orcid.org/0000-0002-1115-4430)
- Hanzhang Lu
Institutions
- University of Vermont (US)
- University of Southern California (US)
- West Los Angeles College (US)
- Harvard University (US)
- University of Kentucky (US)
- Johns Hopkins University (US)
- University of California, Los Angeles (US)
- University of New Mexico (US)
- University of California, San Francisco (US)
- Massachusetts General Hospital (US)
- University Memory and Aging Center (US)
- Institute for Neurodegenerative Disorders (US)
- University of California, Davis (US)
- The University of Texas Health Science Center at Houston (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-18
- DOI
- https://doi.org/10.1002/alz.14408
- Citations
- 8
- Primary Topic
- Cardiovascular Health and Disease Prevention
- Type
- article
- Field-Weighted Citation Impact
- 3.22
Funders
- BrightFocus Foundation
- National Institutes of Health
- National Institute of Neurological Disorders and Stroke