The expanding role of 16s ribosomal RNA PCR in the management of patients with infective endocarditis undergoing cardiac surgery

The molecular test showed significantly higher diagnostic sensitivity than valve culture and maintained this efficacy even after 28 days of preoperative antibiotic therapy. In addition to identifying the pathogen in 7% of cases with negative culture results, the molecular test demonstrated utility in other crucial situations. When valve cultures were negative, combining molecular testing and histopathological analysis they allowed the identification of patients who could benefit from prolonged antibiotic therapy. In addition, molecular testing guided the choice of antibiotic treatment when there was a discrepancy between blood culture and valve culture results. Based on these findings, molecular testing should be considered in all patients with infective endocarditis undergoing cardiac surgery. <b>Clinical Trial Registration</b>: ClinicalTrials.gov, identifier (NCT05791357).

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Publication Details

Journal
Frontiers in Cardiovascular Medicine
Published
2024-12-18
DOI
https://doi.org/10.3389/fcvm.2024.1504197
Citations
2
Primary Topic
Infective Endocarditis Diagnosis and Management
Type
article
Field-Weighted Citation Impact
0.77
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article

The expanding role of 16s ribosomal RNA PCR in the management of patients with infective endocarditis undergoing cardiac surgery

Federico Cammertoni, Giancarlo Scoppettuolo, Natalia Pavone, Giulia Iannaccone et al.
2 citations
Frontiers in Cardiovascular Medicine
Infective Endocarditis Diagnosis and Management
0.77
article

The expanding role of 16s ribosomal RNA PCR in the management of patients with infective endocarditis undergoing cardiac surgery

Federico Cammertoni, Giancarlo Scoppettuolo, Natalia Pavone, Giulia Iannaccone, Andréa Barbará, Eleonora Taddei, Francesca Giovannenze, Antonella Lombardo, Tiziana D’Inzeo, Niccolò Del Zanna, Gessica Cutrone, Massimo Massetti, Piergiorgio Bruno, Maria Calabrese
article en
2 citations

Abstract

The molecular test showed significantly higher diagnostic sensitivity than valve culture and maintained this efficacy even after 28 days of preoperative antibiotic therapy. In addition to identifying the pathogen in 7% of cases with negative culture results, the molecular test demonstrated utility in other crucial situations. When valve cultures were negative, combining molecular testing and histopathological analysis they allowed the identification of patients who could benefit from prolonged antibiotic therapy. In addition, molecular testing guided the choice of antibiotic treatment when there was a discrepancy between blood culture and valve culture results. Based on these findings, molecular testing should be considered in all patients with infective endocarditis undergoing cardiac surgery. <b>Clinical Trial Registration</b>: ClinicalTrials.gov, identifier (NCT05791357).

Frontiers in Cardiovascular MedicineVol. 11
Università Cattolica del Sacro Cuore (IT), Agostino Gemelli University Polyclinic (IT), Istituti di Ricovero e Cura a Carattere Scientifico (IT)
Good health and well-being
Openalex Percentile: Top 24%
Infective Endocarditis Diagnosis and Management
0.77
DOIOpen Access PDFOpenAlex
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The expanding role of 16s ribosomal RNA PCR in the management of patients with infective endocarditis undergoing cardiac surgery — Federico Cammertoni, Giancarlo Scoppettuolo, et al. · Frontiers in Cardiovascular Medicine (2024) | TGRS Research Map | TGRS