Greater baseline cortical atrophy in the dorsal attention network predicts faster clinical decline in Posterior Cortical Atrophy
These results demonstrate the utility of a snapshot measure of cortical atrophy of the dorsal attention network for predicting the rate of subsequent clinical decline in PCA. If replicated, this topographically-specific MRI-based biomarker could be useful as a clinical prognostication tool that facilitates personalized care planning.
Authors
- Alexandra Touroutoglou (ORCID: https://orcid.org/0000-0001-9679-2433)
- Bonnie Wong (ORCID: https://orcid.org/0000-0002-1449-6938)
- Marianne Chapleau (ORCID: https://orcid.org/0000-0001-8917-2594)
- Deepti Putcha (ORCID: https://orcid.org/0000-0001-5575-5572)
- Yuta Katsumi (ORCID: https://orcid.org/0000-0003-0413-747X)
- Bradford Clark Dickerson (ORCID: https://orcid.org/0000-0002-5958-3445)
- Ryan Eckbo
- Scott M. McGinnis
Institutions
- Harvard University (US)
- University of California, San Francisco (US)
- Massachusetts General Hospital (US)
- University Memory and Aging Center (US)
- Athinoula A. Martinos Center for Biomedical Imaging (US)
Publication Details
- Journal
- Alzheimer s Research & Therapy
- Published
- 2024-12-18
- DOI
- https://doi.org/10.1186/s13195-024-01636-z
- Citations
- 7
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 2.70
Funders
- National Institutes of Health