Urinary proteomics identifies distinct immunological profiles of sepsis associated AKI sub-phenotypes
Our findings suggest AKI-SP1 is characterized by a reparative, regenerative phenotype and AKI-SP2 is characterized as an immune and inflammatory phenotype associated with blood bacteremia. We identified shared biology between AKI sub-phenotypes and eventual risk of RRT highlighting potential therapeutic targets. Urine proteomics may be used to non-invasively classify SP2 participants.
Authors
- Neha A. Sathe (ORCID: https://orcid.org/0000-0002-9072-0559)
- Pavan K. Bhatraju (ORCID: https://orcid.org/0000-0002-2606-4366)
- Mark M. Wurfel
- Leila R. Zelnick (ORCID: https://orcid.org/0000-0002-8461-5111)
- Ian B. Stanaway (ORCID: https://orcid.org/0000-0002-0783-0918)
- Sarah Speckmaier
- Jonathan Himmelfarb (ORCID: https://orcid.org/0000-0002-3319-1224)
- F. Linzee Mabrey (ORCID: https://orcid.org/0000-0003-0263-9601)
- Eric D. Morrell (ORCID: https://orcid.org/0000-0001-9900-3604)
- Carmen R. Mikacenic (ORCID: https://orcid.org/0000-0001-8966-5161)
- J.L. Lo (ORCID: https://orcid.org/0000-0002-6164-7065)
- Laura Evans (ORCID: https://orcid.org/0000-0002-3176-6493)
- Zoie A. Bailey
Institutions
- University of Washington (US)
- University of Washington Medical Center (US)
- Benaroya Research Institute
Publication Details
- Journal
- Critical Care
- Published
- 2024-12-18
- DOI
- https://doi.org/10.1186/s13054-024-05202-9
- Citations
- 11
- Primary Topic
- Acute Kidney Injury Research
- Type
- article
- Field-Weighted Citation Impact
- 3.73
Funders
- Bill and Melinda Gates Foundation
- National Institutes of Health
- Centers for Disease Control and Prevention
- National Heart, Lung, and Blood Institute
- National Institute of Diabetes and Digestive and Kidney Diseases