Molecular docking and <i>in vitro</i> evaluation of glucosamine sulfate targeting MMP-3, MMP-9, and IL-4 for potential osteoarthritis treatment

Glucosamine sulfate exhibited stable molecular interactions with genes associated to OA development. However, GS toxicity at high concentrations necessitates future research studies to optimize dosing and assess its therapeutic safety in OA treatment.

Authors

Ponnusamy Palanisamy (ORCID: https://orcid.org/0000-0001-7005-9604)
Selvaraj Kunjiappan (ORCID: https://orcid.org/0000-0002-6741-5118)
Venkataramanan Srinivasan

Institutions

Dhanalakshmi Srinivasan Group of Institutions (IN)
Vellore Institute of Technology University (IN)
Kalasalingam Academy of Research and Education (IN)

Publication Details

Journal: Drug Metabolism and Personalized Therapy
Published: 2024-12-18
DOI: https://doi.org/10.1515/dmpt-2024-0067
Citations: 1
Primary Topic: Osteoarthritis Treatment and Mechanisms
Type: article
Field-Weighted Citation Impact: 0.47

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article

Molecular docking and in vitro evaluation of glucosamine sulfate targeting MMP-3, MMP-9, and IL-4 for potential osteoarthritis treatment

Ponnusamy Palanisamy, Selvaraj Kunjiappan, Venkataramanan Srinivasan

Dec 18, 2024

1 citations

Drug Metabolism and Personalized Therapy

Osteoarthritis Treatment and Mechanisms

0.47

article

Molecular docking and in vitro evaluation of glucosamine sulfate targeting MMP-3, MMP-9, and IL-4 for potential osteoarthritis treatment

Ponnusamy Palanisamy, Selvaraj Kunjiappan, Venkataramanan Srinivasan

December 18, 2024article en

1 citations

Abstract

Glucosamine sulfate exhibited stable molecular interactions with genes associated to OA development. However, GS toxicity at high concentrations necessitates future research studies to optimize dosing and assess its therapeutic safety in OA treatment.

Drug Metabolism and Personalized TherapyVol. 40(1)

Dhanalakshmi Srinivasan Group of Institutions (IN), Vellore Institute of Technology University (IN), Kalasalingam Academy of Research and Education (IN)

Openalex Percentile: Top 29%

Osteoarthritis Treatment and Mechanisms

0.47

DOI Source OpenAlex

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Molecular docking and <i>in vitro</i> evaluation of glucosamine sulfate targeting MMP-3, MMP-9, and IL-4 for potential osteoarthritis treatment — Ponnusamy Palanisamy, Selvaraj Kunjiappan, et al. · Drug Metabolism and Personalized Therapy (2024) | TGRS Research Map | TGRS