Association between the Amplification Parameters of the α‐Synuclein Seed Amplification Assay and Clinical and Genetic Subtypes of Parkinson's Disease
CSF-αSyn-SAA parameters vary across genetic and non-genetic PD subtypes at the group level. These differences are mostly driven by the presence of LRRK2 variants and DysA. Significant overlaps in the amplification parameter values exist between groups and limit their use at the individual level. Further studies are necessary to understand the mechanisms of CSF-αSyn-SAA parameter differences. © 2024 International Parkinson and Movement Disorder Society.
Authors
- Piergiorgio Grillo (ORCID: https://orcid.org/0000-0001-8196-3914)
- Antonio Pisani (ORCID: https://orcid.org/0000-0002-8432-594X)
- Luis Concha‐Marambio (ORCID: https://orcid.org/0000-0002-9454-8389)
- Giulietta Riboldi (ORCID: https://orcid.org/0000-0003-0322-5718)
- Un Jung Kang (ORCID: https://orcid.org/0000-0002-5970-6839)
Institutions
- Neurosciences Institute (US)
- University of Pavia (IT)
- Amprion (United States) (US)
Publication Details
- Journal
- Movement Disorders
- Published
- 2024-12-18
- DOI
- https://doi.org/10.1002/mds.30085
- Citations
- 7
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.58
Funders
- U.S. Department of Defense
- Michael J. Fox Foundation for Parkinson's Research
- Parkinson's Foundation
- Ministero dell'Università e della Ricerca
- National Institutes of Health