Circular RNA circPHLPP2 promotes tumor growth and anti-PD-1 resistance through binding ILF3 to regulate IL36γ transcription in colorectal cancer
Overall, our findings reveal a novel mechanism by which circRNA regulates CRC immune evasion. circPHLPP2 may serve as a prognostic biomarker and potential therapeutic target for CRC patients.
Authors
- De‐Shen Wang (ORCID: https://orcid.org/0000-0001-9657-4380)
- Zerong Cai (ORCID: https://orcid.org/0000-0002-4514-7116)
- Ren‐Ze Huang (ORCID: https://orcid.org/0009-0003-9488-0570)
- Huai‐Qiang Ju (ORCID: https://orcid.org/0000-0003-1713-5465)
- Dongliang Chen (ORCID: https://orcid.org/0000-0002-9067-1654)
- Yan Hu (ORCID: https://orcid.org/0000-0001-7208-1952)
Institutions
- Sun Yat-sen University (CN)
- Sun Yat-sen University Cancer Center (CN)
Publication Details
- Journal
- Molecular Cancer
- Published
- 2024-12-18
- DOI
- https://doi.org/10.1186/s12943-024-02192-8
- Citations
- 17
- Primary Topic
- Circular RNAs in diseases
- Type
- article
- Field-Weighted Citation Impact
- 3.97
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Guangdong Province