Phase II Study of Defactinib (VS6063) in Patients With Tumors With <i>NF2</i> Loss: Results From the NCI-MATCH ECOG-ACRIN Trial (EAY131) Subprotocol U
This protocol did not meet its prespecified primary end point. Defactinib monotherapy had limited clinical activity in this cohort of previously treated patients with solid tumors exhibiting <i>NF2</i> loss.
Authors
- Alice P. Chen (ORCID: https://orcid.org/0000-0002-2919-4326)
- Jose Carrillo (ORCID: https://orcid.org/0009-0003-3336-0336)
- Marjorie G. Zauderer (ORCID: https://orcid.org/0000-0002-6109-5790)
- Lyndsay N. Harris (ORCID: https://orcid.org/0000-0002-9774-6719)
- Keith T. Flaherty (ORCID: https://orcid.org/0000-0002-3402-0478)
- Peter James O'Dwyer (ORCID: https://orcid.org/0000-0002-9302-4073)
- Larry Rubinstein (ORCID: https://orcid.org/0000-0002-9720-9737)
- James A. Zwiebel (ORCID: https://orcid.org/0000-0003-4455-8789)
- P. Mickey Williams
- David R. Patton (ORCID: https://orcid.org/0000-0003-3855-0166)
- Lisa M. McShane (ORCID: https://orcid.org/0000-0001-8195-3206)
- Carlos L. Arteaga (ORCID: https://orcid.org/0000-0003-0870-9586)
- Barbara A. Conley (ORCID: https://orcid.org/0000-0002-1445-1684)
- Raymond Y. Huang (ORCID: https://orcid.org/0000-0001-7661-797X)
- James V. Tricoli (ORCID: https://orcid.org/0000-0003-3975-8516)
- Robert J. Gray (ORCID: https://orcid.org/0000-0002-5724-4917)
- Stanley R. Hamilton (ORCID: https://orcid.org/0000-0002-8331-1052)
- Naoko Takebe (ORCID: https://orcid.org/0000-0002-5790-4954)
- Andrew Brenner (ORCID: https://orcid.org/0000-0002-3985-253X)
- Opeyemi A. Jegede (ORCID: https://orcid.org/0000-0003-1763-8214)
- David M. Jackman
- Victoria Wang
Institutions
- Brigham and Women's Hospital (US)
- City Of Hope National Medical Center (US)
- Westchester Medical Center (US)
- Memorial Sloan Kettering Cancer Center (US)
- The University of Texas at San Antonio Health Science Center (US)
- New York Medical College (US)
- University of California, Irvine (US)
- Cornell University (US)
- Massachusetts General Hospital (US)
- Southwestern Medical Center (US)
- Dana-Farber Cancer Institute (US)
- Frederick National Laboratory for Cancer Research (US)
- National Cancer Institute (US)
- Harold C. Simmons Comprehensive Cancer Center
- University of Pennsylvania (US)
- The University of Texas Southwestern Medical Center (US)
Publication Details
- Journal
- JCO Precision Oncology
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1200/po.24.00327
- Citations
- 3
- Primary Topic
- Neurofibromatosis and Schwannoma Cases
- Type
- article
- Field-Weighted Citation Impact
- 1.11
Funders
- Margaret A. Cargill Foundation
- National Institutes of Health
- National Cancer Institute