Antibiotic Use and Subsequent Cognitive Decline and Dementia Risk in Healthy Older Adults
Among initially healthy older adults, any or repeated antibiotic use was not associated with incident dementia, CIND, or accelerated cognitive decline. Although prescription data may not reflect the actual use, we examined the frequency of antibiotics within a defined period to capture the extent and duration of antibiotic exposure. Our results do not support an association between antibiotic-associated gut microbiome disruption and dementia risk.
Authors
- Jonathan Broder (ORCID: https://orcid.org/0000-0003-0776-1278)
- Robyn L. Woods (ORCID: https://orcid.org/0000-0003-1249-6149)
- Erika J. Ernst
- Michael E. Ernst (ORCID: https://orcid.org/0000-0003-0267-4888)
- Rory Wolfe (ORCID: https://orcid.org/0000-0002-2126-1045)
- Andrew T. Chan (ORCID: https://orcid.org/0000-0001-7284-6767)
- Suzanne Gaye Orchard (ORCID: https://orcid.org/0000-0003-0211-3183)
- Joanne Ryan (ORCID: https://orcid.org/0000-0002-7039-6325)
- Zhen Zhou (ORCID: https://orcid.org/0000-0002-0835-8686)
- Yiqing Wang (ORCID: https://orcid.org/0000-0003-1984-1777)
Institutions
- Monash Institute of Medical Research (AU)
Publication Details
- Journal
- Neurology
- Published
- 2024-12-18
- DOI
- https://doi.org/10.1212/wnl.0000000000210129
- Citations
- 6
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 2.31
Funders
- Pfizer
- National Institutes of Health
- National Cancer Institute