Sphingolipid profiling as a biomarker of type 2 diabetes risk: evidence from the MIDUS and PREDIMED studies
Our findings support the potential usefulness of circulating sphingolipid profiles as novel biomarkers for T2D risk. Moreover, this study opens the door for future research on the predictive value and possible protective roles of lactosylceramides in T2D.
Authors
- Cristián Salazar
- Fiorella Biancardi (ORCID: https://orcid.org/0000-0002-3633-1851)
- Jordi Salas‐Salvadó (ORCID: https://orcid.org/0000-0003-2700-7459)
- Montserrat Fitó (ORCID: https://orcid.org/0000-0002-1817-483X)
- Miguel Ruiz‐Canela (ORCID: https://orcid.org/0000-0002-7684-2787)
- Christopher L. Coe (ORCID: https://orcid.org/0000-0001-9335-9060)
- Cristina Razquín (ORCID: https://orcid.org/0000-0003-3480-2645)
- Attilio Rigotti (ORCID: https://orcid.org/0000-0002-0495-3525)
- Amy Deik (ORCID: https://orcid.org/0000-0002-9687-0953)
- Frank B. Hu (ORCID: https://orcid.org/0000-0002-8233-6274)
- Miguel Ángel Martínez‐González (ORCID: https://orcid.org/0000-0002-3917-9808)
- Emilio Ros (ORCID: https://orcid.org/0000-0002-2573-1294)
- Carol D. Ryff (ORCID: https://orcid.org/0000-0002-4693-9190)
- Dolores Corella
- Loni Berkowitz (ORCID: https://orcid.org/0000-0002-8562-4845)
- Daniel Wang (ORCID: https://orcid.org/0000-0003-4825-4547)
- Ramón Estruch
Institutions
- Broad Institute (US)
- Brigham and Women's Hospital (US)
- University of Wisconsin–Madison (US)
- Harvard University (US)
- Universitat de València (ES)
- Pontificia Universidad Católica de Chile (CL)
- Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition (ES)
- Institut de Recerca Biomèdica Catalunya Sud (ES)
- Institute on Aging (US)
- Consorci Institut D'Investigacions Biomediques August Pi I Sunyer (ES)
- Universitat Rovira i Virgili (ES)
- Universitat de Barcelona (ES)
- Universidad de Navarra (ES)
Publication Details
- Journal
- Cardiovascular Diabetology
- Published
- 2024-12-18
- DOI
- https://doi.org/10.1186/s12933-024-02505-7
- Citations
- 7
- Primary Topic
- Sphingolipid Metabolism and Signaling
- Type
- article
- Field-Weighted Citation Impact
- 1.64
Funders
- John D. and Catherine T. MacArthur Foundation
- University of Washington
- Georgetown University
- Agencia Nacional de Investigación y Desarrollo
- National Institutes of Health
- Instituto de Salud Carlos III
- National Institute on Aging