Single-Cell RNA Sequencing, Cell Communication, and Network Pharmacology Reveal the Potential Mechanism of Senecio scandens Buch.-Ham in Hepatocellular Carcinoma Inhibition

This study revealed that Climbing senecio may target multiple pathways and genes in the process of regulating HCC and exert potential drug effects through a multi-target mechanism, which provides a new idea for the treatment of HCC. However, the research is predicated on network database analysis and bioinformatics, offering insights into HCC therapeutic potential while emphasizing the need for further validation.

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Publication Details

Journal
Pharmaceuticals
Published
2024-12-18
DOI
https://doi.org/10.3390/ph17121707
Citations
7
Primary Topic
Pharmacogenetics and Drug Metabolism
Type
article
Field-Weighted Citation Impact
3.27
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article

Single-Cell RNA Sequencing, Cell Communication, and Network Pharmacology Reveal the Potential Mechanism of Senecio scandens Buch.-Ham in Hepatocellular Carcinoma Inhibition

Xinlei Jiang, Fangfang Han, Yongming Cai, Jiayi Jiang et al.
7 citations
Pharmaceuticals
Pharmacogenetics and Drug Metabolism
3.27
article

Single-Cell RNA Sequencing, Cell Communication, and Network Pharmacology Reveal the Potential Mechanism of Senecio scandens Buch.-Ham in Hepatocellular Carcinoma Inhibition

Xinlei Jiang, Fangfang Han, Yongming Cai, Jiayi Jiang, Qing Ou, Haitao Wu, Z. G. Gan
article en
7 citations

Abstract

This study revealed that Climbing senecio may target multiple pathways and genes in the process of regulating HCC and exert potential drug effects through a multi-target mechanism, which provides a new idea for the treatment of HCC. However, the research is predicated on network database analysis and bioinformatics, offering insights into HCC therapeutic potential while emphasizing the need for further validation.

PharmaceuticalsVol. 17(12)
Guangdong Pharmaceutical University (CN), National Medical Products Administration (CN)
Openalex Percentile: Top 8%
Pharmacogenetics and Drug Metabolism
3.27
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