Single-Cell RNA Sequencing, Cell Communication, and Network Pharmacology Reveal the Potential Mechanism of Senecio scandens Buch.-Ham in Hepatocellular Carcinoma Inhibition
This study revealed that Climbing senecio may target multiple pathways and genes in the process of regulating HCC and exert potential drug effects through a multi-target mechanism, which provides a new idea for the treatment of HCC. However, the research is predicated on network database analysis and bioinformatics, offering insights into HCC therapeutic potential while emphasizing the need for further validation.
Authors
- Xinlei Jiang (ORCID: https://orcid.org/0000-0002-5080-7158)
- Fangfang Han
- Yongming Cai (ORCID: https://orcid.org/0000-0003-0971-8206)
- Jiayi Jiang (ORCID: https://orcid.org/0009-0006-3792-4989)
- Qing Ou
- Haitao Wu (ORCID: https://orcid.org/0000-0002-4804-3806)
- Z. G. Gan (ORCID: https://orcid.org/0000-0002-2927-1475)
Institutions
- Guangdong Pharmaceutical University (CN)
- National Medical Products Administration (CN)
Publication Details
- Journal
- Pharmaceuticals
- Published
- 2024-12-18
- DOI
- https://doi.org/10.3390/ph17121707
- Citations
- 7
- Primary Topic
- Pharmacogenetics and Drug Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 3.27