Determination of the efficacy of the antiviral drug "NanoViroSan" in pigs

Porcine reproductive and respiratory syndrome (PRRS) and porcine parvovirus infection are contagious diseases of pigs characterized by impaired reproductive function in sows, abortions, and the birth of mummified, dead, or weak piglets with high mortality. To date, vaccine prophylaxis has improved reproduction rates, but it does not solve the problem of eradicating the disease completely, and significant economic losses require systematic improvement of means of combating them. The development of new domestic low-toxic and highly active agents with a wide range of antiviral activity will significantly improve the epizootic situation with these viral diseases in the country. The aim of our work was to evaluate the effectiveness of the newly developed drug “NanoViroSan” in sows with reproductive disorders. The study was conducted in a stationary disadvantaged farm on sows with reproductive system damage caused by the association of PRRSV and PVS viruses, with the manifestation of underdeveloped offspring and respiratory disease in young animals. For the treatment of pigs, a drug with antiviral activity “NanoViroSan” was used, which contains Methisazone (inhibits mRNA synthesis in poxviruses) and Amixin (effective against influenza viruses, other acute respiratory viral infections, hepatitis A, B, C, and herpesviruses) with the addition of magnesium nanoxide with bactericidal action. 56 farrowing sows with reproductive disorders were treated with “NanoViroSan” at the rate of 1 cm3/10 kg, in the neck muscles for 3 consecutive days (I course). A total of 7 treatment courses were conducted with an interval of 10 days for 6 months. Production trials of the experimental drug “NanoViroSan” against reproductive and respiratory syndrome in association with parvovirus infection of pigs showed its high efficiency at the level of 95.8% in the recovery from reproductive pathology and reduction of massive abandonment of newborn piglets. The use of the experimental drug “NanoViroSan” allows to increase the safety of young animals and stabilize the epizootic situation regarding reproductive and respiratory syndrome and parvovirus infection of pigs in a permanently disadvantaged farm, which indicates the ability to break the epizootic chain of emergent infection