Acute Liver Failure Caused by Isoniazid during Preventive Treatment for Latent Tuberculosis: A Rare Autopsy Case Report
Treating patients with latent tuberculosis infection (LTBI) to prevent the development of tuberculosis is a fundamental treatment strategy in daily practice. Isoniazid (INH) therapy for 6-12 months is recommended. However, INH can also cause hepatotoxicity. This report describes the autopsy case of a 65-year-old Japanese man diagnosed with LTBI who died of acute liver failure caused by INH.
Authors
- Kazuyuki Ishida (ORCID: https://orcid.org/0000-0002-2804-4588)
- Toshihiko Ohnishi
- Akira Yamamiya (ORCID: https://orcid.org/0000-0002-5158-5606)
- Keiichi Tominaga (ORCID: https://orcid.org/0000-0002-3716-3386)
- Naoya Ikeda (ORCID: https://orcid.org/0000-0002-1498-8713)
- Shuhei Noda (ORCID: https://orcid.org/0000-0002-3006-9055)
- Shunsuke Kojimahara
- Seiji Niho (ORCID: https://orcid.org/0000-0001-9480-5923)
- Yuka Yamazaki (ORCID: https://orcid.org/0000-0001-9147-0291)
- Takahiro Arisaka
- Atsushi Irisawa (ORCID: https://orcid.org/0000-0002-2271-2717)
- Makoto Iijima (ORCID: https://orcid.org/0000-0002-6101-9501)
- M. Tagaya
- Yuichi Majima
Institutions
- Dokkyo Medical University (JP)
Publication Details
- Journal
- Internal Medicine
- Published
- 2024-12-18
- DOI
- https://doi.org/10.2169/internalmedicine.4720-24
- Citations
- 1
- Primary Topic
- Drug-Induced Hepatotoxicity and Protection
- Type
- article
- Field-Weighted Citation Impact
- 0.47
Funders
- Dokkyo Medical University