Expert consensus on a multidisciplinary approach for the management of multiple myeloma-related bone disease

This consensus on multiple myeloma-related bone diseases (MBDs) underscores the importance of a multidisciplinary approach that encompasses hematology, radiology, orthopedics, and additional specialties to tackle its intricate challenges. MBD, a prevalent and debilitating complication of multiple myeloma, leads to bone pain, fractures, and skeletal-related events (SREs), which profoundly impact patients' quality of life. The guidelines offer a thorough framework for diagnosis, treatment, and continual assessment, emphasizing early detection and consistent monitoring using imaging techniques such as positron emission tomography-computed tomography (PET-CT) and magnetic resonance imaging (MRI). Treatment strategies prioritize the careful application of anti-myeloma agents, bisphosphonates, and denosumab to minimize bone loss and decrease SRE risk, complemented by surgical and radiotherapy interventions for structural or pain-related issues. Supportive care measures, including pain management, rehabilitation, nutritional support, and dental evaluations, play a crucial role in enhancing patient outcomes and preserving quality of life. This consensus advocates a standardized, evidence-based approach to managing MBD, ensuring comprehensive and coordinated care for patients.

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Publication Details

Journal
Cancer Pathogenesis and Therapy
Published
2024-12-18
DOI
https://doi.org/10.1016/j.cpt.2024.12.002
Citations
2
Primary Topic
Multiple Myeloma Research and Treatments
Type
article
Field-Weighted Citation Impact
0.91
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article

Expert consensus on a multidisciplinary approach for the management of multiple myeloma-related bone disease

Jinhai Ren, Min Mao, Haiping Yang, Chunrui Li et al.
2 citations
Cancer Pathogenesis and Therapy
Multiple Myeloma Research and Treatments
0.91
article

Expert consensus on a multidisciplinary approach for the management of multiple myeloma-related bone disease

Jinhai Ren, Min Mao, Haiping Yang, Chunrui Li, Jian Hou, Xiaojing Yan, Yuxing Guo, Ying Sun, Jumei Shi, Zeping Zhou, Heng Mei, Junqiang Yin, Rong Fu, Junling Zhuang, Peng Zhao, Xianan Li, Shengjin Fan, Hongmei Jing, Yaozhu Pan, Yanjuan He, Guangxun Gao, Bing-Zong Li, Lichao Sun, Aili He, Yanping Ma, Zhihong Li, Zhiqiang Liu, Weifeng Liu, Jun Luo, Hong Zhang, Yutong Wang, Xuemei Sun, Nan Li, Tang Liu, Yi Wang, Wen-Ming Chen, Zhen Cai, Xuechun Lu, Li-Hua Gong, Yuan Li, Chunyan Sun, Yongbin Su, Yalin Chen, Qiming Xu, Jian Ge, Gang An, Xiaobing Huang, Fuling Zhou, Xiaoquan Wang, Jian‐Qing Mi, Wei Sun, Jing Tan, Xiaobo Wang, Xuehong Ran, Meng Xu, Li-Ye Zhong, Wei Yang, Ling Wang, Yao Liu
article en
2 citations

Abstract

This consensus on multiple myeloma-related bone diseases (MBDs) underscores the importance of a multidisciplinary approach that encompasses hematology, radiology, orthopedics, and additional specialties to tackle its intricate challenges. MBD, a prevalent and debilitating complication of multiple myeloma, leads to bone pain, fractures, and skeletal-related events (SREs), which profoundly impact patients' quality of life. The guidelines offer a thorough framework for diagnosis, treatment, and continual assessment, emphasizing early detection and consistent monitoring using imaging techniques such as positron emission tomography-computed tomography (PET-CT) and magnetic resonance imaging (MRI). Treatment strategies prioritize the careful application of anti-myeloma agents, bisphosphonates, and denosumab to minimize bone loss and decrease SRE risk, complemented by surgical and radiotherapy interventions for structural or pain-related issues. Supportive care measures, including pain management, rehabilitation, nutritional support, and dental evaluations, play a crucial role in enhancing patient outcomes and preserving quality of life. This consensus advocates a standardized, evidence-based approach to managing MBD, ensuring comprehensive and coordinated care for patients.

Cancer Pathogenesis and TherapyVol. 3(4)
Hebei Medical University (CN), Weifang Medical University (CN), Union Hospital (HK), Central South University (CN), Guiyang Medical University (CN), Harbin Medical University (CN), Sun Yat-sen University (CN), Guangxi Medical University (CN), Shanxi Medical University (CN), Shanghai Jiao Tong University (CN), Dalian Medical University (CN), Anhui Medical University (CN), Chinese Academy of Medical Sciences & Peking Union Medical College (CN), Peking University (CN), Kunming Medical University (CN), Beijing Chao-Yang Hospital, Capital Medical University (CN), Renji Hospital (CN), Peking Union Medical College Hospital (CN), Ruijin Hospital (CN), Tianjin Medical University General Hospital (CN), Chinese PLA General Hospital (CN), Beijing Jishuitan Hospital (CN), Wuhan University (CN), Soochow University (CN), Shaanxi Provincial People's Hospital (CN), Third People's Hospital of Chengdu (CN), Second Hospital of Hebei Medical University (CN), Shandong Tumor Hospital (CN), Second Affiliated Hospital of Dalian Medical University (CN), Affiliated Hospital of Taishan Medical University (CN), Affiliated Hospital of Guizhou Medical University (CN), Weifang People's Hospital (CN), 82th Hospital of Pla (CN), Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital (CN), Zhongnan Hospital of Wuhan University (CN), Chifeng Municipal Hospital (CN), People's Hospital of Xinjiang Uygur Autonomous Region (CN), Peking University People's Hospital (CN), Second Affiliated Hospital of Soochow University (CN), First Affiliated Hospital of GuangXi Medical University (CN), Shanghai East Hospital (CN), The First Affiliated Hospital, Sun Yat-sen University (CN), Second Affiliated Hospital of Xi'an Jiaotong University (CN), Second Hospital of Shanxi Medical University (CN), First Affiliated Hospital of Henan University of Science and Technology (CN), Shanghai First People's Hospital (CN), First Affiliated Hospital of Anhui Medical University (CN), First Hospital of China Medical University (CN), Peking University Third Hospital (CN), Guangdong Academy of Medical Sciences (CN), Shanghai Institute of Hematology (CN), Institute of Hematology & Blood Diseases Hospital (CN), Second Xiangya Hospital of Central South University (CN), Guangdong Provincial People's Hospital (CN), Chongqing Cancer Hospital (CN), First Affiliated Hospital of Harbin Medical University (CN), Xijing Hospital (CN), Xiangya Hospital Central South University (CN), Tongji Hospital (CN), Shanxi Provincial People’s Hospital (CN), Jiangsu Provincial Hospital of Traditional Chinese Medicine (CN), Shandong First Medical University (CN), Beijing Chaoyang Emergency Medical Center (CN), First Affiliated Hospital Zhejiang University (CN), Huazhong University of Science and Technology (CN), Southern Medical University (CN), China Medical University (CN)
Good health and well-being
Openalex Percentile: Top 21%
Multiple Myeloma Research and Treatments
0.91
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