Dynamic self-assembled meso-structures formed across a wide concentration range in aqueous solutions of propranolol hydrochloride
There is a continuum of particle sizes shown to exist across the entire concentration range, with molecules joining and leaving on the nanosecond timescale, and with the distributions of aggregate sizes varying with drug and salt concentration. Given that propranolol is a highly prescribed (WHO essential) medicine, disfavouring aggregators from consideration in high-throughput screening for potential new drug candidates - as many have advocated - should thus be done cautiously.
Authors
- Richard A. Campbell (ORCID: https://orcid.org/0000-0002-6296-314X)
- David J. Barlow (ORCID: https://orcid.org/0000-0002-0094-5122)
- Katharina Edkins (ORCID: https://orcid.org/0000-0002-6885-5457)
- James P. Tellam (ORCID: https://orcid.org/0000-0001-9243-1323)
- Yichun Shen (ORCID: https://orcid.org/0000-0003-4519-6097)
- Najet Mahmoudi (ORCID: https://orcid.org/0000-0003-4936-6911)
- Andrew G. Leach (ORCID: https://orcid.org/0000-0003-1325-8273)
- Peixun Li (ORCID: https://orcid.org/0000-0002-7749-1472)
- M.J. Lawrence
- Yixuan Yan
Institutions
- Rutherford Appleton Laboratory (GB)
- University of Strathclyde (GB)
- University of Manchester (GB)
Publication Details
- Journal
- Journal of Colloid and Interface Science
- Published
- 2024-12-18
- DOI
- https://doi.org/10.1016/j.jcis.2024.12.131
- Citations
- 2
- Primary Topic
- Surfactants and Colloidal Systems
- Type
- article
- Field-Weighted Citation Impact
- 0.50
Funders
- China Scholarship Council
- ISIS Neutron and Muon Source