Relative Forgiveness of Different Allopurinol Implementation Patterns in People with Gout and their Impact on Clinical Outcomes: a Simulation Study
Our study provides evidence that missing one or two doses of allopurinol, even repeatedly over a year, does not significantly impact serum urate target achievement or clinical outcomes. However, people who take repeated drug holidays of more than 3 days in a row (followed by less than 15 consecutive days of dosing) are less than 0.3 times as likely (at least 70% less likely) to achieve adequate urate control than those with perfect implementation and may see an increase in the frequency of gout flares.
Authors
- SOPHIE LENA STOCKER (ORCID: https://orcid.org/0000-0002-2114-587X)
- Matthew J. Coleshill (ORCID: https://orcid.org/0000-0003-1906-1893)
- Toni J. F. Michael (ORCID: https://orcid.org/0000-0002-6422-8683)
- Mélanie White‐Koning (ORCID: https://orcid.org/0000-0001-5072-5489)
- Richard Osborne Day (ORCID: https://orcid.org/0000-0002-6045-6937)
- Daniel F. B. Wright (ORCID: https://orcid.org/0000-0001-9313-9252)
- Parisa Aslani (ORCID: https://orcid.org/0000-0002-7976-8236)
- Dyfrig Hughes (ORCID: https://orcid.org/0000-0001-8247-7459)
Institutions
- The University of Sydney (AU)
- Université Toulouse III - Paul Sabatier (FR)
- Inserm (FR)
- Bangor University (GB)
- Black Dog Institute (AU)
- UNSW Sydney (AU)
- St Vincent's Hospital Melbourne (AU)
- St Vincent's Hospital Sydney (AU)
- Centre de Recherches en Cancérologie de Toulouse (FR)
- St Vincent’s Private Hospital Sydney (AU)
- Institute for Musculoskeletal Health (AU)
- St Vincent's Clinic (AU)
Publication Details
- Journal
- Clinical Pharmacokinetics
- Published
- 2024-12-18
- DOI
- https://doi.org/10.1007/s40262-024-01467-z
- Citations
- 1
- Primary Topic
- Gout, Hyperuricemia, Uric Acid
- Type
- article
- Field-Weighted Citation Impact
- 0.34
Funders
- University of Sydney