Personalized neoantigen hydrogel vaccine combined with PD-1 and CTLA-4 double blockade elicits antitumor response in liver metastases by activating intratumoral CD8<sup>+</sup>CD69<sup>+</sup> T cells
This study demonstrated that NPT-gels combined with PCDB could exert a durable and powerful antitumor immunity by enhancing the recruitment and activation of CD8<sup>+</sup>CD69<sup>+</sup> T cells, which supports the rationale and clinical translation of this combination strategy and provides important evidence for further improving the immunotherapy efficacy of liver metastases in the future.
Authors
- Aimin Ge
- Huan Yang (ORCID: https://orcid.org/0000-0002-8690-2544)
- Shichuan Tang (ORCID: https://orcid.org/0000-0003-1744-5068)
- Ruijing Tang (ORCID: https://orcid.org/0009-0008-5129-2097)
- Yongyi Zeng (ORCID: https://orcid.org/0000-0001-7441-4271)
- Tingfeng Huang (ORCID: https://orcid.org/0000-0002-6440-3664)
- Ming Wu (ORCID: https://orcid.org/0000-0001-8326-4076)
- Jun Fu (ORCID: https://orcid.org/0000-0001-5968-8231)
- Qizhu Lin
- Xiaowei Yin (ORCID: https://orcid.org/0000-0002-9291-2941)
- Kongying Lin (ORCID: https://orcid.org/0000-0001-8886-4054)
- Xiaolong Liu (ORCID: https://orcid.org/0000-0002-3096-4981)
- Geng Chen (ORCID: https://orcid.org/0000-0002-2320-2161)
- Da Zhang (ORCID: https://orcid.org/0000-0002-2613-1354)
- Xiuqing Dong (ORCID: https://orcid.org/0000-0001-7510-1904)
- Yutong Guo (ORCID: https://orcid.org/0000-0002-3712-8353)
- Zhixiong Cai (ORCID: https://orcid.org/0000-0002-0912-8372)
- Jie Kong
- Fangzhou Lin
Institutions
- Fujian Medical University (CN)
- Xian Central Hospital (CN)
- Mengchao Hepatobiliary Hospital (CN)
- First Affiliated Hospital of Fujian Medical University (CN)
- Heze Municipal Hospital (CN)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1136/jitc-2024-009543
- Citations
- 12
- Primary Topic
- Immunotherapy and Immune Responses
- Type
- article
- Field-Weighted Citation Impact
- 2.89
Funders
- National Natural Science Foundation of China