Computational assessment of the binding modes of the first VHL-recruiting PROTACs designed for oncogenic KRas<sup>G12C</sup>
The representative ternary complexes revealed a predominant binding mode for all compounds, with the two proteins approaching each other in the same orientation.
Authors
- Maximilian C. C. J. C. Ebert (ORCID: https://orcid.org/0000-0002-8055-8404)
- Steven R. LaPlante (ORCID: https://orcid.org/0000-0003-2835-5789)
- Michael L. Drummond (ORCID: https://orcid.org/0000-0002-4688-3975)
- Tanos C. C. França (ORCID: https://orcid.org/0000-0002-6048-8103)
- Eleonore K. M. Delaire (ORCID: https://orcid.org/0000-0002-6930-8244)
- Al Ajamian
Institutions
- Institut National de la Recherche Scientifique (CA)
- Military Institute of Engineering (BR)
- University of Hradec Králové (CZ)
Publication Details
- Journal
- New Journal of Chemistry
- Published
- 2024-12-18
- DOI
- https://doi.org/10.1039/d4nj03612c
- Citations
- 3
- Primary Topic
- Protein Degradation and Inhibitors
- Type
- article
- Field-Weighted Citation Impact
- 0.70
Funders
- Québec Consortium for Drug Discovery
- Mitacs