Identification of a novel subtype of SPP1 + macrophages expressing SIRPα: implications for tumor immune evasion and treatment response prediction
A novel subtype of SPP1 + macrophages expressing SIRPα was identified and their abundance predicted patients' response to PD-1/PD-L1 inhibitors.
Authors
- Zhengfei Zhu (ORCID: https://orcid.org/0000-0001-7537-3619)
- Jianjiao Ni (ORCID: https://orcid.org/0000-0003-3113-2586)
- Silai Yu
- Hongru Chen (ORCID: https://orcid.org/0000-0001-9453-6962)
- Ruiting Ye
- Kun Chen (ORCID: https://orcid.org/0000-0003-0577-0998)
- Yue Zhou (ORCID: https://orcid.org/0000-0003-4012-4270)
- Yida Li (ORCID: https://orcid.org/0000-0002-4578-3489)
- Yechun Pang
- Xi Yang (ORCID: https://orcid.org/0000-0001-9647-9316)
- Peng Wang (ORCID: https://orcid.org/0000-0002-5716-9937)
Institutions
- Shanghai Medical College of Fudan University (CN)
- Fudan University (CN)
- Fudan University Shanghai Cancer Center (CN)
- Suzhou Municipal Hospital (CN)
- Zhongshan Hospital (CN)
- Shanghai Institute of Hematology (CN)
- Shanghai Clinical Research Center (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Experimental Hematology and Oncology
- Published
- 2024-12-18
- DOI
- https://doi.org/10.1186/s40164-024-00587-3
- Citations
- 7
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 1.68
Funders
- Beijing Xisike Clinical Oncology Research Foundation
- National Natural Science Foundation of China
- Beijing Medical and Health Foundation