Onset of age, site and respiratory symptoms are strongly associated with respiratory decline in sporadic amyotrophic lateral sclerosis: a long-term longitudinal study
Our findings revealed strong and independent patient-specific factors that influence the Onset-REP duration and the %VC decline rate in patients with ALS. These could inform future clinical trials and interventions considering the respiratory function and natural history of patients with ALS.
Authors
- Yasunobu Nosaki
- Ryota Torii
- Naofumi Miura
- Yu Sasaki (ORCID: https://orcid.org/0000-0003-3322-4900)
- Atsunori Murao
- Shin-ichi Terao
- Nanayo Ogawa
- Gen Sobue
Institutions
- ROHM (JP)
- Aichi Medical University (JP)
- Mie University (JP)
- Kasugai Municipal Hospital (JP)
- Yokkaichi Social Insurance Hospital (JP)
- Toyohashi Municipal Hospital (JP)
- Higashi Nagoya National Hospital (JP)
Publication Details
- Journal
- BMJ Neurology Open
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1136/bmjno-2024-000829
- Primary Topic
- Amyotrophic Lateral Sclerosis Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00