CLOCK gene 3’UTR and exon 9 polymorphisms show a strong association with essential hypertension in a North Indian population
This is a first report linking circadian rhythm gene polymorphisms with EH in any Indian population. The statistically significant association of the CLOCK gene 3'UTR and exon 9 polymorphisms with EH, highlight the potential role of this gene and probably other genes of the circadian pathway in the etiology of EH in the study population. Additionally, our study also revealed that certain genotypes are making males more susceptible to EH.
Authors
- Arti Dhar (ORCID: https://orcid.org/0000-0003-1892-6875)
- Medha Medha
- Audesh Bhat (ORCID: https://orcid.org/0000-0002-2892-3910)
- Sonali Bhan
- Rakesh Kumar (ORCID: https://orcid.org/0000-0001-5606-5215)
- Sonal Saxena (ORCID: https://orcid.org/0000-0001-6126-805X)
- Shreya Sopori
- Kavinay Kavinay
Institutions
- University of Jammu (IN)
- Birla Institute of Technology and Science - Hyderabad Campus (IN)
- Central University of Jammu (IN)
- Shri Mata Vaishno Devi University (IN)
Publication Details
- Journal
- BMC Medical Genomics
- Published
- 2024-12-18
- DOI
- https://doi.org/10.1186/s12920-024-02056-6
- Citations
- 4
- Primary Topic
- Circadian rhythm and melatonin
- Type
- article
- Field-Weighted Citation Impact
- 1.10
Funders
- Indian Council of Medical Research