Microglia in the aged brain develop a hypoactive molecular phenotype after surgery
While anesthesia and surgery induce pro-inflammatory changes in the plasma and brain of mice, microglia adopt a homeostatic molecular phenotype following surgery. This effect seems to be more pronounced in aged mice and is transient. These results challenge the prevailing assumption that surgery activates microglia in the aged brain.
Authors
- Zhongcong Xie (ORCID: https://orcid.org/0000-0002-0720-1759)
- Zhuoran Yin (ORCID: https://orcid.org/0000-0002-8525-0062)
- Oleg Butovsky (ORCID: https://orcid.org/0000-0003-0186-8867)
- Deborah J. Culley (ORCID: https://orcid.org/0000-0002-1003-2407)
- Sebastian Silveira
- Anna K. Leonard (ORCID: https://orcid.org/0009-0007-1962-2650)
- Gregory Crosby
- Carl M. Porto
Institutions
- Brigham and Women's Hospital (US)
- Massachusetts Eye and Ear Infirmary (US)
- Harvard University (US)
- Massachusetts General Hospital (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- Journal of Neuroinflammation
- Published
- 2024-12-18
- DOI
- https://doi.org/10.1186/s12974-024-03307-0
- Citations
- 1
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.25
Funders
- BrightFocus Foundation
- Cure Alzheimer's Fund
- Broad Institute
- National Institutes of Health
- National Institute of Neurological Disorders and Stroke