D609 Suppresses Antituberculosis Response by Regulating Dendritic Cells Antigen Presentation
Our findings suggest that PC-PLC plays a critical role in the functionality of DCs, including the production of chemokines and pro-inflammatory cytokines, migration to lymph nodes, and antigen presentation to T cells, which collectively contribute to T cell activation and effective clearance of Mycobacterium tuberculosis. Further investigation into the regulatory mechanisms of PC-PLC in DCs may uncover novel therapeutic targets for the development of advanced anti-TB treatments.
Authors
- Zhen Huang (ORCID: https://orcid.org/0000-0002-6856-3147)
- Lianhui Liang (ORCID: https://orcid.org/0000-0001-6958-0443)
- Haihui Yang (ORCID: https://orcid.org/0009-0001-7736-6188)
- Shuwen Chen (ORCID: https://orcid.org/0000-0003-1245-1469)
- Huimin Huang (ORCID: https://orcid.org/0000-0003-0038-4334)
- Yingxuan Chen (ORCID: https://orcid.org/0000-0002-1883-7736)
- Honglin Liu (ORCID: https://orcid.org/0000-0001-8136-4014)
- Xiaoni Wang (ORCID: https://orcid.org/0000-0003-3068-600X)
- Deyou Tan
- Xiaoni Pang
Institutions
- Zhongshan City Second People's Hospital (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Immunity Inflammation and Disease
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/iid3.70103
- Primary Topic
- Immune Response and Inflammation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Zhongshan Science and Technology Bureau