A hybrid epithelial-mesenchymal transition program enables basal epithelial cells to bypass stress-induced stasis and contributes to a metaplastic breast cancer progenitor state
This study reveals how an epigenetic program governs basal epithelial cell fate decisions and contributes to the development of MBC progenitors by restricting access to terminal mesenchymal states that induce growth arrest and, instead, favoring hybrid EMT states with enhanced tumorigenic potential.
Authors
- Joseph A. Caruso (ORCID: https://orcid.org/0000-0003-2900-3996)
- Chira Chen‐Tanyolac
- Thea D. Tlsty
Institutions
- University of California, San Francisco (US)
Publication Details
- Journal
- Breast Cancer Research
- Published
- 2024-12-18
- DOI
- https://doi.org/10.1186/s13058-024-01920-8
- Citations
- 5
- Primary Topic
- Cancer Cells and Metastasis
- Type
- article
- Field-Weighted Citation Impact
- 1.41
Funders
- California Breast Cancer Research Program
- Cancer Research UK
- National Institutes of Health
- University of California, San Francisco
- National Cancer Institute