The effects and mechanisms of chai shao jie yu granules on chronic unpredictable mild stress (CUMS)-induced depressive rats based on network pharmacology
CSJY demonstrated the ability to alleviate depressive behaviors in CUMS-induced depression rats, potentially through the inhibition of the hypothalamic-pituitary-adrenal (HPA) axis, modulation of monoamine neurotransmitters, and glutamatergic neurons. These findings suggest that CSJY could serve as a promising treatment option for depression.
Authors
- Qin Tang (ORCID: https://orcid.org/0000-0003-0362-6271)
- Xiaoxu Fan (ORCID: https://orcid.org/0000-0001-8505-6668)
- Bing Han (ORCID: https://orcid.org/0000-0002-3523-0573)
- Chang Hong-sheng (ORCID: https://orcid.org/0000-0003-1699-5551)
- Xue Yu (ORCID: https://orcid.org/0000-0002-7703-0764)
- Nan Sun (ORCID: https://orcid.org/0009-0007-5142-227X)
- Yu Li (ORCID: https://orcid.org/0000-0002-9077-9294)
- Lina Li (ORCID: https://orcid.org/0000-0003-4503-6683)
- Liying Liu (ORCID: https://orcid.org/0000-0001-8560-3035)
- Haolin Chu
- Xiuli Wang
Institutions
- Beijing University of Chinese Medicine (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Chinese University of Hong Kong, Shenzhen (CN)
- Education Department of Heilongjiang Province (CN)
Publication Details
- Journal
- Journal of Ethnopharmacology
- Published
- 2024-12-19
- DOI
- https://doi.org/10.1016/j.jep.2024.119268
- Citations
- 8
- Primary Topic
- Metabolomics and Mass Spectrometry Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.87