Sanguinarine suppresses oral squamous cell carcinoma progression by targeting the PKM2/TFEB aix to inhibit autophagic flux
Our results demonstrate for the first time that Sang can suppress the PKM2/TFEB axis, and influence lysosomal function, thereby blocking autophagy and inhibiting the progression of OSCC, making it a promising therapeutic option for the treatment of OSCC.
Authors
- Yi Jiang (ORCID: https://orcid.org/0000-0002-3725-0148)
- Ding-Zhou Zhou
- Keyan Li (ORCID: https://orcid.org/0000-0003-0467-6684)
- Kai Wang (ORCID: https://orcid.org/0000-0002-0137-1247)
- Jia Xie (ORCID: https://orcid.org/0000-0003-4472-760X)
- Chenyao Li (ORCID: https://orcid.org/0000-0002-5061-8189)
- Zhiyuan Zhang (ORCID: https://orcid.org/0000-0001-8569-7326)
- Jian Zhang (ORCID: https://orcid.org/0000-0002-2211-3327)
- Li Tian (ORCID: https://orcid.org/0000-0003-1497-7923)
- Xiaowei Xie (ORCID: https://orcid.org/0000-0001-6309-9800)
- Huifeng Pi (ORCID: https://orcid.org/0000-0001-6219-5171)
- Zhijing He
- Yong-Chun Peng
- Guan-Ying Feng
- Lun-cai Yin
- Tengfei Fan (ORCID: https://orcid.org/0009-0006-3830-9291)
Institutions
- Central South University (CN)
- Army Medical University (CN)
- Hunan Normal University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Shanghai Ninth People's Hospital (CN)
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- Second Xiangya Hospital of Central South University (CN)
- Chongqing Dazu District People's Hospital (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Phytomedicine
- Published
- 2024-12-19
- DOI
- https://doi.org/10.1016/j.phymed.2024.156337
- Citations
- 17
- Primary Topic
- Berberine and alkaloids research
- Type
- article
- Field-Weighted Citation Impact
- 7.61