Microglial Nrf2-mediated lipid and iron metabolism reprogramming promotes remyelination during white matter ischemia
Weakened Nrf2-mediated antioxidant responses in microglia induced metabolic disturbances and ferroptosis during chronic cerebral hypoperfusion. Targeted enhancement of Nrf2 expression in microglia may be a potential therapeutic strategy for ischemic white matter injury.
Authors
- Ting Xu (ORCID: https://orcid.org/0000-0001-6123-9814)
- Chuanbo Qin (ORCID: https://orcid.org/0000-0001-7189-5196)
- Yilin Lu (ORCID: https://orcid.org/0009-0001-5862-6570)
- Xiao‐Wei Pang
- Ming‐Hao Dong (ORCID: https://orcid.org/0000-0003-2662-8958)
- Yun‐Hui Chu
- Dai‐Shi Tian (ORCID: https://orcid.org/0000-0002-7627-0811)
- Ke Shang (ORCID: https://orcid.org/0009-0003-6648-9048)
- Wei Wang (ORCID: https://orcid.org/0000-0002-5273-3332)
- Lian Chen (ORCID: https://orcid.org/0000-0002-5917-6110)
- Hang Zhang (ORCID: https://orcid.org/0000-0001-7639-0031)
- Sheng Yang (ORCID: https://orcid.org/0000-0003-4226-2159)
- Luyang Zhang (ORCID: https://orcid.org/0000-0003-2620-9251)
- Lulu Xu (ORCID: https://orcid.org/0000-0003-1082-1067)
- Luo-Qi Zhou
- Li‐Fang Zhu
Institutions
- Sun Yat-sen University (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Redox Biology
- Published
- 2024-12-19
- DOI
- https://doi.org/10.1016/j.redox.2024.103473
- Citations
- 14
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 3.46