Zi Shen Wan Fang repaired blood–brain barrier integrity in diabetic cognitive impairment mice via preventing cerebrovascular cells senescence
Our study reveals that ZSWF can ameliorate cognitive function in DCI mice by repairing BBB integrity, and the specific mechanism of which may be related to preventing cerebrovascular cells senescence, and mangiferin is its key active ingredient.
Authors
- Ruibing Su (ORCID: https://orcid.org/0000-0001-5594-4808)
- Qingsheng Yin (ORCID: https://orcid.org/0000-0002-8577-5539)
- Jie Bu (ORCID: https://orcid.org/0000-0002-8546-8715)
- Yanjun Zhang (ORCID: https://orcid.org/0000-0002-9702-1128)
- Ying Li (ORCID: https://orcid.org/0000-0002-1661-5152)
- Pengwei Zhuang (ORCID: https://orcid.org/0000-0003-4308-3654)
- Han Zhang (ORCID: https://orcid.org/0000-0002-6645-8810)
- Genhui Yang
Institutions
- Tianjin University of Traditional Chinese Medicine (CN)
- First Teaching Hospital of Tianjin University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Chinese Medicine
- Published
- 2024-12-18
- DOI
- https://doi.org/10.1186/s13020-024-01041-6
- Citations
- 4
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.99
Funders
- National Natural Science Foundation of China
- Tianjin University