Electrical Impedance Tomography-Based Evaluation of Anesthesia-Induced Development of Atelectasis in Obese Patients

<b>Background/Objectives:</b> The induction of general anesthesia leads to the development of atelectasis and redistribution of ventilation to non-dependent lung regions with subsequent impairment of gas exchange. However, it remains unclear how rapidly atelectasis occurs after the induction of anesthesia in obese patients. We therefore investigated the extent of atelectasis formation in obese patients in the first few minutes after the induction of general anesthesia and initiation of mechanical ventilation in the operating room. <b>Methods</b>: In 102 patients with morbid obesity (BMI ≥ 35 kg m^-2) scheduled for laparoscopic intrabdominal surgery, induction of general anesthesia was performed while continuously monitoring regional pulmonary ventilation using electrical impedance tomography. Distribution of ventilation to non-dependent lung areas as a surrogate for atelectasis formation was determined by taking the mean value of five consecutive breaths for each minute starting five minutes before to five minutes after intubation. Ventilation inhomogeneity was assessed using the Global Inhomogeneity Index. <b>Results</b>: Median tidal volume in non-dependent lung areas was 58.3% before and 71.5% after intubation and increased by a median of 13.79% after intubation (<i>p</i> < 0.001). Median Global Inhomogeneity Index was 49.4 before and 71.4 after intubation and increased by a median of 21.99 units after intubation (<i>p</i> < 0.001). <b>Conclusions</b>: Atelectasis forms immediately after the induction of general anesthesia and increases the inhomogeneity of lung ventilation.