Evaluating data requirements for high-quality haplotype-resolved genomes for creating robust pangenome references
Our study provides insights into optimal data types and volumes for robust de novo genome assembly in population-level pangenome projects. Reassessing the recommended data types and volumes in this study and aligning them with practical economic limitations are vital to the pangenome research community, contributing to their efforts and pushing genomic studies with broader impacts.
Authors
- Mile Šikić (ORCID: https://orcid.org/0000-0002-8370-0891)
- Josipa Lipovac (ORCID: https://orcid.org/0009-0003-4943-5179)
- Filip Tomas
- Prasad Sarashetti
- Jianjun Liu (ORCID: https://orcid.org/0000-0002-3255-3019)
Institutions
- Agency for Science, Technology and Research (SG)
- National University of Singapore (SG)
- University of Zagreb (HR)
- Genome Institute of Singapore (SG)
Publication Details
- Journal
- Genome biology
- Published
- 2024-12-18
- DOI
- https://doi.org/10.1186/s13059-024-03452-y
- Citations
- 9
- Primary Topic
- Genomics and Phylogenetic Studies
- Type
- article
- Field-Weighted Citation Impact
- 2.10
Funders
- Oxford Nanopore Technologies
- European Commission
- Agency for Science, Technology and Research
- Hrvatska Zaklada za Znanost
- Genome Institute of Singapore
- European Regional Development Fund