SQUiD: ultra-secure storage and analysis of genetic data for the advancement of precision medicine
Cloud computing allows storing the ever-growing genotype-phenotype datasets crucial for precision medicine. Due to the sensitive nature of this data and varied laws and regulations, additional security measures are needed to ensure data privacy. We develop SQUiD, a secure queryable database for storing and analyzing genotype-phenotype data. SQUiD allows storage and secure querying of data in a low-security, low-cost public cloud using homomorphic encryption in a multi-client setting. We demonstrate SQUiD's practical usability and scalability using synthetic and UK Biobank data.
Authors
- Caline S. Karam (ORCID: https://orcid.org/0000-0002-0622-8888)
- Gamze Gürsoy (ORCID: https://orcid.org/0000-0002-1352-8686)
- Jiayi Kang (ORCID: https://orcid.org/0000-0002-1093-7978)
- Thomas Lehner (ORCID: https://orcid.org/0000-0002-1889-1214)
- Jacob Blindenbach (ORCID: https://orcid.org/0009-0009-6498-4399)
- Seungwan Hong
Institutions
- New York Genome Center (US)
- Columbia University (US)
- KU Leuven (BE)
Publication Details
- Journal
- Genome biology
- Published
- 2024-12-18
- DOI
- https://doi.org/10.1186/s13059-024-03447-9
- Citations
- 3
- Primary Topic
- Cryptography and Data Security
- Type
- article
- Field-Weighted Citation Impact
- 1.04
Funders
- National Science Foundation
- Warren Alpert Foundation
- Vlaamse regering
- National Institutes of Health
- National Human Genome Research Institute
- National Institute of General Medical Sciences