Spatial transcriptome profiling identifies DTX3L and BST2 as key biomarkers in esophageal squamous cell carcinoma tumorigenesis
Spatial profiling comprehensively characterized the molecular and immunological hallmarks from normal tissue to ESCC, guiding the way to a deeper understanding of the tumorigenesis and progression of this disease and contributing to the prevention of ESCC. Within this exploration, we uncovered biomarkers that exhibit a robust correlation with ESCC progression, offering potential new avenues for insightful therapeutic approaches.
Authors
- Haitao Huang (ORCID: https://orcid.org/0000-0002-2396-4959)
- Wei Jiang (ORCID: https://orcid.org/0000-0002-2209-3450)
- Rutao Li (ORCID: https://orcid.org/0000-0003-3121-8021)
- Yu Feng (ORCID: https://orcid.org/0000-0001-7416-9034)
- Guangbin Li (ORCID: https://orcid.org/0000-0003-2112-4742)
- Jun Zhao (ORCID: https://orcid.org/0000-0002-6702-0319)
- Haitao Luo (ORCID: https://orcid.org/0000-0003-3671-7786)
- Qianqian Yang (ORCID: https://orcid.org/0000-0001-5821-4333)
- Shaomu Chen (ORCID: https://orcid.org/0000-0001-9590-3525)
- Na Li (ORCID: https://orcid.org/0000-0001-6163-1648)
- Chang Li (ORCID: https://orcid.org/0000-0001-9588-8118)
- Haitao Ma (ORCID: https://orcid.org/0000-0002-9107-2928)
- Jiamin Yuan
- Dong Jiang
- Tong Xing (ORCID: https://orcid.org/0000-0003-1561-4614)
- Fang Chen (ORCID: https://orcid.org/0000-0002-5082-8960)
- Kai Xie
- Dongfang Wu
- Zhibo Gao
- Xiaoli Cui
- Lingchuan Guo (ORCID: https://orcid.org/0000-0002-1028-9296)
- Wei J. Wang (ORCID: https://orcid.org/0000-0002-4848-7394)
Institutions
- Soochow University (CN)
- First Affiliated Hospital of Soochow University (CN)
Publication Details
- Journal
- Genome Medicine
- Published
- 2024-12-18
- DOI
- https://doi.org/10.1186/s13073-024-01422-4
- Citations
- 20
- Primary Topic
- Macrophage Migration Inhibitory Factor
- Type
- article
- Field-Weighted Citation Impact
- 4.81
Funders
- National Natural Science Foundation of China