Data mining in FAERS: association of newer-generation H1-antihistamines with nervous system disorders
Neurological AEs associated with individual newer generation H1-antihistamines of interest varies a lot, whereas somnolence was the most common AE reports. Fexofenadine was highly associated with headaches. Sedative effects associated with levocetirizine and cetirizine should arouse more concern. Seizures significantly associated with levocetirizine and desloratadine were infrequently reported, further research is needed to avoid possible serious outcomes. Patients taking cetirizine probably have higher risk of dystonia and anticholinergic syndrome.
Authors
- Weiping Hu (ORCID: https://orcid.org/0000-0002-1607-8713)
- Chenghong Feng
- Jing Gan (ORCID: https://orcid.org/0000-0001-5255-6324)
- Linan Zeng (ORCID: https://orcid.org/0000-0001-9892-2000)
- Li Chen (ORCID: https://orcid.org/0000-0002-9650-497X)
- Hailong Li (ORCID: https://orcid.org/0000-0001-5284-1897)
- Lingli Zhang (ORCID: https://orcid.org/0000-0003-3832-4046)
Institutions
- National Medical Products Administration (CN)
- Sichuan University (CN)
- West China Second University Hospital of Sichuan University (CN)
- West China Hospital of Sichuan University (CN)
- Maternal and Child Health Hospital of Sichuan Province (CN)
Publication Details
- Journal
- BMC Pharmacology and Toxicology
- Published
- 2024-12-18
- DOI
- https://doi.org/10.1186/s40360-024-00822-x
- Citations
- 4
- Primary Topic
- Drug-Induced Adverse Reactions
- Type
- article
- Field-Weighted Citation Impact
- 1.79
Funders
- National Natural Science Foundation of China