Comprehensive Mendelian randomization analysis of low-density lipoprotein cholesterol and multiple cancers
Analyses using both the HMGCR and PCSK9 genes have shown that LDL-C may be a potential risk factor for breast and prostate cancer, while analyses of the HMGCR gene have also suggested that LDL-C may increase the risk of thyroid cancer and decrease the risk of colorectal cancer.
Authors
- Chunling Tang (ORCID: https://orcid.org/0000-0002-5930-8742)
- Haozhao Liang (ORCID: https://orcid.org/0000-0002-2950-8559)
- Mingwei Wang (ORCID: https://orcid.org/0000-0003-2312-9563)
- Qinquan Gao (ORCID: https://orcid.org/0000-0003-0352-6027)
- Hui Xie (ORCID: https://orcid.org/0000-0002-8490-1695)
- Tong Tong (ORCID: https://orcid.org/0000-0003-0636-7359)
- Tao Tan (ORCID: https://orcid.org/0000-0001-5403-0887)
- Yue Sun
Institutions
- King's College London (GB)
- Affiliated Hospital of Hangzhou Normal University (CN)
- Xiangnan University (CN)
- Macao Polytechnic University (MO)
- Fuzhou University (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2024-12-18
- DOI
- https://doi.org/10.1007/s12672-024-01684-9
- Citations
- 2
- Primary Topic
- Cancer, Lipids, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.57