Tyrosine phosphatase SHP2 promoted the progression of CRC via modulating the PI3K/BRD4/TFEB signaling induced ferroptosis
SHP2 advances CRC progression by modulating TFEB-mediated ferritinophagy, suppressing ROS and ferroptosis. Targeting SHP2 presents a promising therapeutic strategy for CRC.
Authors
- Duancheng Wen (ORCID: https://orcid.org/0000-0002-3160-6289)
- Jiao Cheng (ORCID: https://orcid.org/0000-0003-0820-7762)
- Wu Li (ORCID: https://orcid.org/0000-0002-0752-3643)
- Jian Chen (ORCID: https://orcid.org/0000-0001-7535-6499)
- Cheng Zhang (ORCID: https://orcid.org/0009-0008-2698-5019)
Institutions
- Bethune International Peace Hospital (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2024-12-18
- DOI
- https://doi.org/10.1007/s12672-024-01586-w
- Citations
- 4
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 1.68