A comparison of routine [68Ga]Ga-PSMA-11 preparation using Locametz and Illuccix kits
Both kits benefited from using a syringe pump to elute the <sup>68</sup>Ge/<sup>68</sup>Ga generator, vial agitation, and longer length/smaller bore silicone coated needles. Both kits have similar workflows, comparable QC outcomes, and result in equivalent clinical images. Thus, the decision between kits will ultimately be determined by production preferences. Since radiopharmacies have an established "kit-based" workflow, Locametz kits with higher allowed activities and longer shelf-life may offer benefits. Conversely, more traditional PET manufacturing facilities might benefit from using Illuccix kits due to compatibility with cyclotron-produced [<sup>68</sup>Ga]GaCl<sub>3</sub> allowing for kit batching. Ultimately, the commercial availability of 2 approved kits for production of [<sup>68</sup>Ga]Ga-PSMA-11 PET has facilitated ready access to this important new imaging agent.
Authors
- Ka Kit Wong (ORCID: https://orcid.org/0009-0006-0837-7816)
- Peter J. H. Scott (ORCID: https://orcid.org/0000-0002-6505-0450)
- A. F. Brooks (ORCID: https://orcid.org/0000-0003-4295-792X)
- Ivan Wang (ORCID: https://orcid.org/0000-0002-1318-9522)
- Luke J. Morrissette
- Marianna Dakanali (ORCID: https://orcid.org/0000-0003-2894-0136)
Institutions
- University of Michigan (US)
Publication Details
- Journal
- EJNMMI Radiopharmacy and Chemistry
- Published
- 2024-12-18
- DOI
- https://doi.org/10.1186/s41181-024-00317-4
- Citations
- 6
- Primary Topic
- Medical Imaging Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 2.43
Funders
- University of Michigan