Aging and head and neck cancer insights from single cell and spatial transcriptomic analyses
We utilized single-cell sequencing and spatial transcriptomics to explore the cellular characteristics of HNSCC and its interaction with the tumor microenvironment. Our findings reveal that HNSCC tissues show increased mononuclear cells and demonstrate enhanced activity in ARGs, thereby advancing our understanding of HNSCC development mechanisms.
Authors
- Yuheng Gu (ORCID: https://orcid.org/0000-0003-0209-3450)
- Siyu Liu (ORCID: https://orcid.org/0000-0001-8049-7771)
- Nan Xiong
- Zihao Mou (ORCID: https://orcid.org/0000-0002-1359-5176)
- Hao Chi (ORCID: https://orcid.org/0000-0002-7898-2599)
- Hui Luo (ORCID: https://orcid.org/0000-0001-6312-9299)
- Jie Min (ORCID: https://orcid.org/0000-0001-6140-4461)
- Ke Xu (ORCID: https://orcid.org/0000-0001-7222-9523)
- Jinyan Yang
- Yi Pei (ORCID: https://orcid.org/0000-0002-6547-8721)
- Lai Jiang (ORCID: https://orcid.org/0000-0002-4639-8136)
- Xiangyu Xu (ORCID: https://orcid.org/0000-0003-2694-5240)
- Lingyi Sunzhang
Institutions
- Southwest Medical University (CN)
- Nanchong Central Hospital (CN)
- First People's Hospital of Chongqing (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2024-12-18
- DOI
- https://doi.org/10.1007/s12672-024-01672-z
- Citations
- 12
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 2.81
Funders
- Southwest Medical University