ZDHHC20 mediated S-palmitoylation of fatty acid synthase (FASN) promotes hepatocarcinogenesis
Our findings demonstrate the critical role of ZDHHC20 in promoting hepatocarcinogenesis, and a mechanism underlying a mutual restricting mode for protein palmitoylation and ubiquitination modifications.
Authors
- Bo Xu (ORCID: https://orcid.org/0009-0001-4690-4414)
- Yaqi Mo
- FU Chun-ling
- Mingming Xiao (ORCID: https://orcid.org/0000-0003-0862-2501)
- Yang Chen (ORCID: https://orcid.org/0000-0001-6993-4870)
- Qing Li (ORCID: https://orcid.org/0000-0003-2652-6070)
- Zhuang Liu (ORCID: https://orcid.org/0000-0001-8938-0086)
- Yamei Han
Institutions
- Chongqing University (CN)
- Tianjin Medical University Cancer Institute and Hospital (CN)
- Chongqing Cancer Hospital (CN)
Publication Details
- Journal
- Molecular Cancer
- Published
- 2024-12-19
- DOI
- https://doi.org/10.1186/s12943-024-02195-5
- Citations
- 41
- Primary Topic
- Cancer, Lipids, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 11.69
Funders
- National Natural Science Foundation of China
- Centre Scientifique et Technique du Bâtiment