Ultrasound nanodroplets loaded with Siglec-G siRNA and Fe3O4 activate macrophages and enhance phagocytosis for immunotherapy of triple-negative breast cancer
This work suggests that activating macrophages and enhancing phagocytosis to remodel the TME could be an effective strategy for macrophage-based triple-negative breast cancer immunotherapy.
Authors
- Yaqin Hu (ORCID: https://orcid.org/0000-0002-9328-7201)
- Nianhong Wu
- Guojuan Wang
- Ci Yin
- Fang Nie (ORCID: https://orcid.org/0000-0001-9725-1743)
- Li Pan (ORCID: https://orcid.org/0000-0002-3499-6067)
- Qi Li (ORCID: https://orcid.org/0000-0001-5409-0249)
- Qin Zhang (ORCID: https://orcid.org/0000-0002-4597-7697)
- Qiang Li (ORCID: https://orcid.org/0000-0002-4384-8226)
- Tiantian Dong (ORCID: https://orcid.org/0000-0003-3100-5624)
- Haitao Ran (ORCID: https://orcid.org/0000-0002-3820-1970)
- Yang Cao (ORCID: https://orcid.org/0000-0003-3111-5751)
Institutions
- Dalian Medical University (CN)
- Second Affiliated Hospital of Chongqing Medical University (CN)
- Lanzhou University Second Hospital (CN)
- First People's Hospital of Chongqing (CN)
- Lanzhou University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Journal of Nanobiotechnology
- Published
- 2024-12-19
- DOI
- https://doi.org/10.1186/s12951-024-03051-w
- Citations
- 12
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 2.89
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Chongqing
- Centre Scientifique et Technique du Bâtiment