Unmasking culprits: novel analysis identifies complement factors as potential therapeutic targets to mitigate inflammation during children's heart surgery
Activated complement factors, but not pro-inflammatory cytokines or chemokines, were most related to cardiopulmonary dysfunction and prolonged recovery in this novel analysis. Investigation of therapies that inhibit complement to dampen CPB-associated inflammation and enhance recovery after pediatric cardiac surgery is warranted. Trial Registration ClinicalTrials.gov, NCT05154864.
Authors
- Mark Henderson (ORCID: https://orcid.org/0000-0003-0923-1158)
- David J. de L. Horne (ORCID: https://orcid.org/0000-0002-4721-9099)
- Roger Stanzel
- Joel Bierer (ORCID: https://orcid.org/0000-0002-4579-5674)
- Pantelis Andreou
- John L. Sapp (ORCID: https://orcid.org/0000-0002-9602-2751)
- Jean S. Marshall (ORCID: https://orcid.org/0000-0002-5642-1379)
Institutions
- Dalhousie University (CA)
- Nova Scotia Health Authority (CA)
Publication Details
- Journal
- European journal of medical research
- Published
- 2024-12-19
- DOI
- https://doi.org/10.1186/s40001-024-02156-0
- Citations
- 7
- Primary Topic
- Kawasaki Disease and Coronary Complications
- Type
- article
- Field-Weighted Citation Impact
- 4.01
Funders
- Dalhousie Medical Research Foundation
- Nova Scotia Department of Health and Wellness
- Dalhousie University
- Killam Trusts
- Department of Health, Western Cape Government
- IWK Health Centre
- Research Nova Scotia